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IGNOU MZO-05 (January 2026 – December 2026) Assignment Questions

1. a). Describe the steps of genome data analysis.
b). Write a note on Yeast Artificial Chromosome.

2. a). Distinguish between temporal and site-specific analyses of gene expression.
b). Outline the technique of Isotope Coded Affinity Tag.

3. a). Elucidate the different techniques of western blotting.
b). Distinguish between Matrix Assisted Laser Desorption Ionization and Electrospray Ionization.

4. a). Write a brief note on MALDI-TOF-TOF mass spectrometry.
b). How would you prepare a microarray?

5. a). Explain Whole Genome Shotgun Sequencing Methods with diagram.
b). Write a note on Multiple Sequence Alignment.

6. a). Explain the technique of nuclear run-on assay with diagram.
b). Outline the principle of cDNA-AFLP with diagram.

7. Give a broad overview of the protein mining strategy. What is affinity chromatography?

8. Write a note on the principle and methodology of RNA Sequencing with diagram. Explain Cot curve analysis.

9. Discuss the genome organization of Drosophila and mammals. Mention the characteristics of microsatellites.

10. Write notes on:
a). Structure of globin genes
b). Pseudogenes

IGNOU MZO-05 (January 2025 – December 2025) Assignment Questions

1. Give a broad overview of the organization of viral genomes.

2. Describe the two repeat elements, LINE and SINE with proper diagrams.

3. Describe the different methods for locating genes in a genome sequence.

4. Discuss the principle, methodology and advantages of RNA Sequencing.

5. Given an outline of the chemical sequencing method of DNA with proper illustrations.

6. Discuss the different methods for the prediction of specific domains in proteins.

7. Discuss the different types of ion detectors in mass spectrometry.

8. Give a broad overview of Bacterial Artificial Chromosome and Yeast Artificial Chromosome.

9. Highlight the different applications of RNA interference technology.

10. Write short notes:

a) Yeast two-hybrid system

b) Suppression subtractive hybridization

c) Phage display for DNA binding proteins

d) Chemical ionization in mass spectrometry

MZO-05 Assignments Details

University	:	IGNOU (Indira Gandhi National Open University)
Title	:	Genomics and Proteomics
Language(s)	:	English
Code	:	MZO-05
Degree	:	MSCZOO
Subject	:	Zoology
Course	:	Core Courses (CC)
Author	:	Gullybaba.com Panel
Publisher	:	Gullybaba Publishing House Pvt. Ltd.

IGNOU MZO-05 (Jan 26 - Dec 26, Jan 25 - Dec 25) - Solved Assignment

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